Materials and Biology

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Materials and Biology

Developing « living » materials

The Materials and Biology team, coordinated by Gervaise Mosser ( Researcher at CNRS), gathers chemists, biologists et physicists working on the development of « living » materials, based on a better understanding of cell-materials interactions. Our strategy relies on the integration of the specific functions of biology (self-organization, molecular recognition, enzymatic activity, cellular metabolism,…) within polymer, hybrid or inorganic materials and nanomaterials, to create biomimetic biomaterials, design new biotechnological devices and develop innovative processes in environmental science.

Our research is based on five fields of expertise:

Axis 1 : Biomimetic approaches of tissular processes (G. Mosser)
Axis 2 : Biomaterials : from design to clinics (C. Hélary) 
Axis 3 : Chemistry and bio-applications of silica (T. Coradin)
Axis 4 : Processing techniques for biomaterials (F. M. Fernandes)
Axis 5 : Physics of bio-interfaces (A. Hamraoui & L. Trichet) 

with additional support of C. Roux in inorganic synthesis (incl. metallogels) and S. Masse in materials characterization (incl. solid state NMR)

Our fields of application in the medical and environnemental area take advantage of the gathering of these expertises together with a wide network of national and international pluri-disciplinar collaborations. Among current research topics:

– Biomimetic artificial cornea
–  Collagen-based nanocomposite materials for the treatment of cutaneous chronic wounds
– Antibacterial surfaces
– Electroactive substrates for axonal regeneration
– 3D models of the intervertebral disk
– Additive manufacturing of biomaterials for cardiac repair
– New approaches to fibrin-based materials with tissue repair capabilities
– Cytocompatible cryo-processes for bioremediation and health

 Our research benefits from the technical assistance of B. Haye and C. Illoul for histology and TEM sample preparation.

Selected recent publications
E. Palierse, C. Hélary, J.-M. Krafft, I. Génois, S. Masse, G. Laurent, M. I. Alvarez Echazu, M. Selmane, S. Casale, A.  Miche, B. C.L. Chan, C.B.S. Lau, M. Ip, M. F. Desimone, T. Coradin, C. Jolivalt. Baicalein-modified hydroxyapatite nanoparticles and coatings with antibacterial and antioxidant properties.  Mater. Sci. Eng. C 118, 111537 (2021)   ⟨10.1016/j.msec.2020.111537⟩⟨hal-02456407⟩
K. Qin, C. Eschenbrenner, F. Ginot, D. Dedovets, T. Coradin, S. Deville, F. Fernandes. Unveiling Cells’ Local Environment During Cryopreservation by Correlative In Situ Spatial and Thermal Analyses.  J. Phys. Chem. Lett. 11, 7730-7738 (2020) – ⟨10.1021/acs.jpclett.0c01729⟩⟨hal-02970802⟩
K. Wang, K. Albert, G. Mosser, B. Haye, A. Percot, C. Paris, C. Peccate, L. Trichet, T. Coradin. Self-assembly/condensation interplay in nano-to-microfibrillar silicified fibrin hydrogelsInt. J. Biol. Macromol. 164, 1422-1431 (2020) – ⟨10.1016/j.ijbiomac.2020.07.220⟩⟨hal-02924505⟩
A. Frayssinet, D. Petta, C. Illoul, B. Haye, A. Markitantova, D. Eglin, G. Mosser, M. D’Este, C. Hélary. Extracellular matrix-mimetic composite hydrogels of cross-linked hyaluronan and fibrillar collagen with tunable properties and ultrastructure. Carbohydrate Polym., 236, 116042 (2020) 10.1016/j.carbpol.2020.116042⟨hal-02862482
N. Debons, D. Dems, C. Hélary, S. Le Grill, L. Picaut, F. Renaud-Paitra, N. Delsuc, M.C. Schanne-Klein, T. Coradin, C. Aimé. Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites Biomater. Sci., 8, 2020, 569-576 (2020) ⟨10.1039/c9bm01029g⟩⟨hal-02456407⟩

Main recent collaborators
International: Universidad de Buenos Aires (Argentine), University of Galway (Ireland), AO Fundation (Suisse), Université Mohammed V-Agdal (Maroc).
National: ITODYS (CNRS-Université de Paris), LOB (Ecole Polytechnique), LRS (CNRS-UPMC), EA2496 (Université de Paris), IBPS (INSERM-SU), CIRB (INSERM-Collège de France), Centre de Recherche des Cordeliers (INSERM-SU),  INSP (CNRS-SU), LBM (CNRS-SU-ENS), ICMPE (CNRS-UPEC), Institut de Myologie (INSERM-SU),  Institut de la Vision (CHNO XV-XX), LVTS (INSERM- Université de Paris), IPCM (CNRS-SU).